I managed to split my thumb open, as a glorious conclusion to my... interesting... weekend. With it bandaged like it is, I can't flex my thumb at the knuckle more than a few degrees. I went to strap on my snubbie Taurus a little while ago, and when I went to check load (a habit I'm glad I'm in), I found that I can't readily manipulate the cylinder release with my bandaged thumb. Well, crap, let's try the 1911. The slick tape makes releasing the safety a less than certain proposition. I tried my 1006, and I can flip the safety on that just fine, plus it always gets carried in Condition 2 (round chambered, hammer down, safety off).
Just something to check anytime something changes on your gun hand, no matter how temporary.